Shedding “UV” Light on Endogenous Opioid Dependence
نویسندگان
چکیده
Excessive sun tanning can result in addictive behavior. In this issue of Cell, Fell et al. utilize a combination of behavioral pharmacology and transgenic mice to demonstrate that chronic UV light exposure recruits p53 signaling in keratinocytes, subsequently increasing β-endorphin signaling at opioid receptors, and produces an endogenous opioid-dependent state.
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ورودعنوان ژورنال:
- Cell
دوره 157 شماره
صفحات -
تاریخ انتشار 2014